' 
![]()
SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7.8
USERS' SCORE
Good
Based on 5 Reviews
8.4
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin D3 (as Cholecalciferol) (from Lanolin)
125 mcg (5,000 IU)
625%
Top Medical Research Studies
8
Vitamin D deficiency linked to UTI
The Association between Vitamin D Levels and Urinary Tract Infection in Children.
Directly investigates vitamin D's effect
We aimed to explore the possible connection between vitamin D levels and urinary tract infections (UTIs) in children. Our study involved measuring various health markers, including vitamin D levels, in 82 children who had experienced their first UTI and compared these results to 64 healthy controls.
The findings revealed that children with UTIs had significantly lower levels of vitamin D compared to their healthy peers. Specifically, those with acute pyelonephritis exhibited even lower vitamin D levels than those with lower UTIs. We also noted that girls tended to have lower vitamin D levels than boys.
Multivariate analysis indicated that a vitamin D level below 20 ng/ml was associated with a higher likelihood of UTIs in children. Therefore, our results suggest that vitamin D deficiency may indeed pose a risk for urinary tract infections in this population.
The findings revealed that children with UTIs had significantly lower levels of vitamin D compared to their healthy peers. Specifically, those with acute pyelonephritis exhibited even lower vitamin D levels than those with lower UTIs. We also noted that girls tended to have lower vitamin D levels than boys.
Multivariate analysis indicated that a vitamin D level below 20 ng/ml was associated with a higher likelihood of UTIs in children. Therefore, our results suggest that vitamin D deficiency may indeed pose a risk for urinary tract infections in this population.
Read More
8
Vitamin D supports bladder health
Vitamin D strengthens the bladder epithelial barrier by inducing tight junction proteins during E. coli urinary tract infection.
Strong relevance to UTI prevention
We explored the potential benefits of vitamin D in tackling urinary tract infections (UTIs) caused by the bacterium E. coli. The study involved mice with varying levels of vitamin D, which were infected to imitate UTIs. Additionally, we collected bladder biopsies from postmenopausal women before and after three months of vitamin D supplementation.
Interestingly, while vitamin D showed no significant effect on tight junction proteins in bladder cells before any infection, it did have a notable positive impact during the infections. Specifically, we observed that vitamin D helped to induce important proteins called occludin and claudin-14 in the bladder's upper surface cells. This is key because these proteins play a critical role in strengthening the bladder's epithelial barrier, thereby potentially limiting bacterial invasion.
Our findings suggest that vitamin D supplementation could be a useful strategy for restoring and maintaining the integrity of the bladder lining during E. coli infections, making it a promising avenue for individuals prone to UTIs. However, it is important to emphasize that more research is needed to fully understand these effects and how they can be harnessed in everyday health practices.
Interestingly, while vitamin D showed no significant effect on tight junction proteins in bladder cells before any infection, it did have a notable positive impact during the infections. Specifically, we observed that vitamin D helped to induce important proteins called occludin and claudin-14 in the bladder's upper surface cells. This is key because these proteins play a critical role in strengthening the bladder's epithelial barrier, thereby potentially limiting bacterial invasion.
Our findings suggest that vitamin D supplementation could be a useful strategy for restoring and maintaining the integrity of the bladder lining during E. coli infections, making it a promising avenue for individuals prone to UTIs. However, it is important to emphasize that more research is needed to fully understand these effects and how they can be harnessed in everyday health practices.
Read More
8
Vitamin D3 strengthens immunity against UTIs
The impact of vitamin D on the innate immune response to uropathogenic Escherichia coli during pregnancy.
Directly investigates vitamin D's effect
We explored the link between vitamin D3 and the body's ability to resist urinary tract infections (UTIs) during pregnancy. Our study involved analyzing serum samples from pregnant Ugandan women at different stages of pregnancy, as well as samples from women after childbirth and those who were never pregnant.
Our findings revealed that as pregnancy progressed, levels of vitamin D3 and a specific antimicrobial peptide called LL-37 increased, peaking in the third trimester. Interestingly, women who had been pregnant before (multigravidae) showed higher vitamin D levels compared to first-time mothers (primigravidae).
We also noted that the levels of interleukin-8 (a marker of inflammation) were lower in the third trimester than in the first, suggesting a refined immune response towards the end of pregnancy. Overall, the serum from these women demonstrated a heightened capacity to inhibit E. coli growth, which is a common cause of UTIs. This suggests that rising vitamin D levels might help bolster the body's defenses against infections as pregnancy advances.
Thus, we found that vitamin D3 could play an important role in enhancing the innate immune response during pregnancy, potentially offering some protection against UTIs.
Our findings revealed that as pregnancy progressed, levels of vitamin D3 and a specific antimicrobial peptide called LL-37 increased, peaking in the third trimester. Interestingly, women who had been pregnant before (multigravidae) showed higher vitamin D levels compared to first-time mothers (primigravidae).
We also noted that the levels of interleukin-8 (a marker of inflammation) were lower in the third trimester than in the first, suggesting a refined immune response towards the end of pregnancy. Overall, the serum from these women demonstrated a heightened capacity to inhibit E. coli growth, which is a common cause of UTIs. This suggests that rising vitamin D levels might help bolster the body's defenses against infections as pregnancy advances.
Thus, we found that vitamin D3 could play an important role in enhancing the innate immune response during pregnancy, potentially offering some protection against UTIs.
Read More
Most Useful Reviews
9.5
Improved immunity
I purchased this vitamin as I lack sunlight. I've felt fatigued and suffered from pain in my back and legs, likely due to vitamin D3 deficiency. After six days of taking it, I noticed increased energy, improved mood, and less pain. It’s beneficial for immunity and may assist in preventing respiratory infections.
Read More
9.5
Enhanced resilience
I have taken D3 for a year, with no winter illnesses for me and my husband. My complexion has improved, and I have experienced fewer bruises under my eyes. After struggling for 8 years, I successfully became pregnant. For thrush or cystitis symptoms, increasing my dose resolves issues quickly.
Read More
9.5
Family immunity boost
My family takes vitamin D daily, which supports bone, muscle, and nervous system health. Studies show that many COVID-19 patients had low vitamin D levels. I take 5000 units daily, and it helps reduce the risk of respiratory infections. Each family member has their own dosage to ensure optimal vitamin intake.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7.8
9
Hybrid protein vaccination study results
Immunization with recombinant protein Ag43::UpaH with alum and 1,25(OH)2D3 adjuvants significantly protects Balb/C mice against urinary tract infection caused by uropathogenic Escherichia coli.
Vitamin D3's isolated effect unclear
We explored how combining a hybrid protein with Vitamin D3 and alum might protect against urinary tract infections (UTIs) caused by uropathogenic Escherichia coli (UPEC). This study involved immunizing mice with a new protein made from two virulence factors, Ag43 and UpaH, along with these adjuvants.
The results were promising; we found that the addition of alum or both alum and Vitamin D3 significantly boosted immune responses, particularly in IgG levels and other immune markers. Mice that received these combinations showed a marked reduction in bacterial load in the bladder and kidneys compared to those who were not given these treatments.
However, it’s important to note that while Vitamin D3 was included, its specific effects when separated from the other components could not be precisely evaluated in this study. This means while it seems to be beneficial in tandem with alum, we can't confirm how effective it is on its own for UTI prevention. Overall, our findings indicate that the Ag43::UpaH hybrid protein combined with adjuvants like alum and Vitamin D3 could be a promising avenue for UTI vaccine development.
The results were promising; we found that the addition of alum or both alum and Vitamin D3 significantly boosted immune responses, particularly in IgG levels and other immune markers. Mice that received these combinations showed a marked reduction in bacterial load in the bladder and kidneys compared to those who were not given these treatments.
However, it’s important to note that while Vitamin D3 was included, its specific effects when separated from the other components could not be precisely evaluated in this study. This means while it seems to be beneficial in tandem with alum, we can't confirm how effective it is on its own for UTI prevention. Overall, our findings indicate that the Ag43::UpaH hybrid protein combined with adjuvants like alum and Vitamin D3 could be a promising avenue for UTI vaccine development.
Read More
8
Vitamin D supports bladder health
Vitamin D strengthens the bladder epithelial barrier by inducing tight junction proteins during E. coli urinary tract infection.
Strong relevance to UTI prevention
We explored the potential benefits of vitamin D in tackling urinary tract infections (UTIs) caused by the bacterium E. coli. The study involved mice with varying levels of vitamin D, which were infected to imitate UTIs. Additionally, we collected bladder biopsies from postmenopausal women before and after three months of vitamin D supplementation.
Interestingly, while vitamin D showed no significant effect on tight junction proteins in bladder cells before any infection, it did have a notable positive impact during the infections. Specifically, we observed that vitamin D helped to induce important proteins called occludin and claudin-14 in the bladder's upper surface cells. This is key because these proteins play a critical role in strengthening the bladder's epithelial barrier, thereby potentially limiting bacterial invasion.
Our findings suggest that vitamin D supplementation could be a useful strategy for restoring and maintaining the integrity of the bladder lining during E. coli infections, making it a promising avenue for individuals prone to UTIs. However, it is important to emphasize that more research is needed to fully understand these effects and how they can be harnessed in everyday health practices.
Interestingly, while vitamin D showed no significant effect on tight junction proteins in bladder cells before any infection, it did have a notable positive impact during the infections. Specifically, we observed that vitamin D helped to induce important proteins called occludin and claudin-14 in the bladder's upper surface cells. This is key because these proteins play a critical role in strengthening the bladder's epithelial barrier, thereby potentially limiting bacterial invasion.
Our findings suggest that vitamin D supplementation could be a useful strategy for restoring and maintaining the integrity of the bladder lining during E. coli infections, making it a promising avenue for individuals prone to UTIs. However, it is important to emphasize that more research is needed to fully understand these effects and how they can be harnessed in everyday health practices.
Read More
8
Cholecalciferol helps prevent UTIs
Cholecalciferol for the prophylaxis against recurrent urinary tract infection among patients with benign prostatic hyperplasia: a randomized, comparative study.
Moderate relevance due to study design.
We explored the potential benefits of cholecalciferol, commonly known as vitamin D3, in preventing recurrent urinary tract infections (UTIs) among patients with benign prostatic hyperplasia (BPH).
In this study, we followed 389 men suffering from moderate to severe BPH symptoms for two years. The patients were divided into two groups: one received tamsulosin, a standard medication to treat BPH, while the other group received both tamsulosin and cholecalciferol.
Our findings revealed that the group treated with cholecalciferol had a significantly lower incidence of UTIs—4.6% compared to 13.5% in the group receiving only tamsulosin. Additionally, the patients who took vitamin D3 experienced a lower level of prostate-specific antigen (PSA) at the end of the treatment, suggesting a potential added benefit.
Overall, cholecalciferol supplementation appears to offer protective effects against recurrent UTIs for BPH patients on tamsulosin, and it does this without introducing any extra adverse effects.
In this study, we followed 389 men suffering from moderate to severe BPH symptoms for two years. The patients were divided into two groups: one received tamsulosin, a standard medication to treat BPH, while the other group received both tamsulosin and cholecalciferol.
Our findings revealed that the group treated with cholecalciferol had a significantly lower incidence of UTIs—4.6% compared to 13.5% in the group receiving only tamsulosin. Additionally, the patients who took vitamin D3 experienced a lower level of prostate-specific antigen (PSA) at the end of the treatment, suggesting a potential added benefit.
Overall, cholecalciferol supplementation appears to offer protective effects against recurrent UTIs for BPH patients on tamsulosin, and it does this without introducing any extra adverse effects.
Read More
8
Vitamin D deficiency increases UTI risk
Vitamin D deficiency is an independent risk factor for urinary tract infections after renal transplants.
Study correlates deficiency with UTIs
We examined the effects of vitamin D deficiency on the occurrence of urinary tract infections (UTIs) in patients who had undergone kidney transplants. The study involved 410 participants, and we measured their vitamin D levels using 25-hydroxyvitamin D3 prior to their transplants.
Our findings revealed that 41.7% of these patients were vitamin D deficient, with levels below 10 ng/mL. Over an average follow-up period of 7.3 years, vitamin D-deficient patients experienced significantly more UTIs compared to those with adequate vitamin D levels. In fact, 30.4% of vitamin D-deficient patients had a UTI, in contrast to 16.7% of those who were not deficient.
Through our analysis, we established that vitamin D deficiency is an independent risk factor for developing UTIs after kidney transplant surgery. Thus, checking and managing vitamin D levels could play an important role in predicting and possibly reducing UTI complications in kidney transplant recipients.
Our findings revealed that 41.7% of these patients were vitamin D deficient, with levels below 10 ng/mL. Over an average follow-up period of 7.3 years, vitamin D-deficient patients experienced significantly more UTIs compared to those with adequate vitamin D levels. In fact, 30.4% of vitamin D-deficient patients had a UTI, in contrast to 16.7% of those who were not deficient.
Through our analysis, we established that vitamin D deficiency is an independent risk factor for developing UTIs after kidney transplant surgery. Thus, checking and managing vitamin D levels could play an important role in predicting and possibly reducing UTI complications in kidney transplant recipients.
Read More
8
Vitamin D3 strengthens immunity against UTIs
The impact of vitamin D on the innate immune response to uropathogenic Escherichia coli during pregnancy.
Directly investigates vitamin D's effect
We explored the link between vitamin D3 and the body's ability to resist urinary tract infections (UTIs) during pregnancy. Our study involved analyzing serum samples from pregnant Ugandan women at different stages of pregnancy, as well as samples from women after childbirth and those who were never pregnant.
Our findings revealed that as pregnancy progressed, levels of vitamin D3 and a specific antimicrobial peptide called LL-37 increased, peaking in the third trimester. Interestingly, women who had been pregnant before (multigravidae) showed higher vitamin D levels compared to first-time mothers (primigravidae).
We also noted that the levels of interleukin-8 (a marker of inflammation) were lower in the third trimester than in the first, suggesting a refined immune response towards the end of pregnancy. Overall, the serum from these women demonstrated a heightened capacity to inhibit E. coli growth, which is a common cause of UTIs. This suggests that rising vitamin D levels might help bolster the body's defenses against infections as pregnancy advances.
Thus, we found that vitamin D3 could play an important role in enhancing the innate immune response during pregnancy, potentially offering some protection against UTIs.
Our findings revealed that as pregnancy progressed, levels of vitamin D3 and a specific antimicrobial peptide called LL-37 increased, peaking in the third trimester. Interestingly, women who had been pregnant before (multigravidae) showed higher vitamin D levels compared to first-time mothers (primigravidae).
We also noted that the levels of interleukin-8 (a marker of inflammation) were lower in the third trimester than in the first, suggesting a refined immune response towards the end of pregnancy. Overall, the serum from these women demonstrated a heightened capacity to inhibit E. coli growth, which is a common cause of UTIs. This suggests that rising vitamin D levels might help bolster the body's defenses against infections as pregnancy advances.
Thus, we found that vitamin D3 could play an important role in enhancing the innate immune response during pregnancy, potentially offering some protection against UTIs.
Read More
User Reviews
USERS' SCORE
Good
Based on 5 Reviews
8.4
9.5
Improved immunity
I purchased this vitamin as I lack sunlight. I've felt fatigued and suffered from pain in my back and legs, likely due to vitamin D3 deficiency. After six days of taking it, I noticed increased energy, improved mood, and less pain. It’s beneficial for immunity and may assist in preventing respiratory infections.
Read More
9.5
Enhanced resilience
I have taken D3 for a year, with no winter illnesses for me and my husband. My complexion has improved, and I have experienced fewer bruises under my eyes. After struggling for 8 years, I successfully became pregnant. For thrush or cystitis symptoms, increasing my dose resolves issues quickly.
Read More
9.5
Family immunity boost
My family takes vitamin D daily, which supports bone, muscle, and nervous system health. Studies show that many COVID-19 patients had low vitamin D levels. I take 5000 units daily, and it helps reduce the risk of respiratory infections. Each family member has their own dosage to ensure optimal vitamin intake.
Read More
8
Enhanced immune response
I have been taking vitamin D-3 daily with meals for three months. I feel my body copes better with colds and viral infections. Previously, illnesses progressed quickly, requiring stronger interventions. Now, my immune system manages initial symptoms with less effort. Overall, D-3 is a reliable support for our immune health, especially during a pandemic.
Read More
3.5
Potential complications
I took 5000 IU of Vitamin D and choline daily and developed urinary stones. I'm unsure if the choline helped the vitamin or if both contributed to this issue. While the product isn’t strictly good or bad, I learned that too much of anything can be detrimental, particularly regarding urinary tract infections.
Read More
